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Is Dianabol a Banned Steroid or a Legal Supplement
A bill of lading (/ ˈleɪdɪŋ /) (sometimes abbreviated as B/L or BOL) is a document issued by a carrier (or their agent) to acknowledge receipt of cargo for shipment. Although the term historically related only to carriage by sea, a bill of lading may today be used for any type of carriage of goods. See full list on drugs.com. The carrier may also note on the bill of lading that the shipment was received in good condition (Clean BOL). Order Bill of Lading. An Order BOL refers to the scenario where delivery is dependent on the seller being paid. This makes the bill of lading a powerful tool, that, when endorsed, acts as collateral or can be traded as a security.
Dianabol once contained the now-banned ingredients metandienone and methandrostenolone. Dianabol, sold under the brand name of CiBa Labs. The ingredient methandrostenolone, no longer used in medicine in the United States. The extensive side effects forced the FDA to discontinue all Dianabol products containing methandrostenolone. Even though effective Dianabol alternatives, uninformed bodybuilders still use the old D-Bol and choose to accept the possible risks. Taken orally by mouth in capsule form.
Side Effects of Methenandrostenolone
Side effects 0f methandrostenolone may include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire, estrogenic effects like fluid retention and breast enlargement, and liver damage. The drug is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT), and has strong anabolic effects and moderate androgenic effects. It also has moderate estrogenic effects.
Dianabol e.g, D-BOL, originally developed in 1955 by CIBA and marketed in Germany and the United States. As the CIBA product Dianabol, Dianabol e.g, D-BOL quickly became the first widely used AAS among professional and amateur athletes, and remains the most common orally active AAS for non-medical use. It is currently a controlled substance in the United States and United Kingdom and remains popular among bodybuilders. Dianabol e.g, D-BOL (absent of the ingredient Methandrostenolone) is now established as a dietary supplement, and is readily available without a prescription in certain countries.
Previous Medical Uses
Dianabol e.g, D-BOL was formerly approved and marketed for the treatment of hypogonadism, but has since been discontinued and withdrawn in most countries. As of the removal of the ingredient methandrostenolone, Dianabol is presently available as an over-the-counter dietary supplement in the USA.
Use For Muscle Building
Dianabol, or D-BOL, is used as a bodybuilding supplement for it’s performance-enhancing purposes. Competitive athletes, bodybuilders, and powerlifters use it for muscle growth, recovery, and strength promotion. It is said to be the most widely used legal-steroid for such purposes both today.
Side Effects and Safer Alternatives
Androgenic side effects such as oily skin, acne, seborrhea, increased facial/body hair growth, scalp hair loss, and virilization may occur. Estrogenic side effects such as gynecomastia and fluid retention can also occur, but is not typical with the legal dianabol supplements. As with other 17α-alkylated steroids, methandrostenolone poses a risk of hepatotoxicity and use over extended periods of time can result in liver damage without appropriate precautions. Diandrobol by Muscle Labs USA is non-methylated and poses little to no risk when taken at recomended doses.
Pharmacology
Methandrostenolone binds to and activates the androgen receptor (AR) in order to exert its effects. These include dramatic increases in protein synthesis, glycogenolysis, and muscle strength over a short space of time.[medical citation needed] While it can be metabolized by 5α-reductase into methyl-1-testosterone (17α-methyl-δ1-DHT), a more potent AAS, the drug has extremely low affinity for this enzyme and methyl-1-testosterone is thus produced in only trace amounts. As such, 5α-reductase inhibitors like finasteride and dutasteride do not reduce the androgenic effects of Dianabol e.g, D-BOL. Nonetheless, while the ratio of anabolic to androgenic activity of Dianabol e.g, D-BOL improved relative to that of testosterone, the supplement does still possess moderate androgenic activity, capable of producing severe virilization in women and children. As such, only really commonly used in men.
Methandrostenolone, a substrate for aromatase, metabolized into the estrogen methylestradiol (17α-methylestradiol). While the rate of aromatization reduced relative to that for testosterone or methyltestosterone, the estrogen produced is metabolism-resistant. The Dianabol supplement e.g, D-BOL retains little estrogenic activity. As such, side effects such as gynecomastia and fluid retention not expected with the legal Dianabol. The co-administration of an antiestrogen such as an aromatase inhibitor like anastrozole or a selective estrogen receptor modulator like tamoxifen will reduce or prevent estrogenic side effects. D-BOL has no progestogenic activity.
As with other 17α-alkylated AAS, Methandrostenolone is hepatotoxic, however the new Dianabol e.g, D-BOL supplements are NOT.
Pharmacokinetics
Dianabol e.g, D-BOL has high oral bioavailability. It has very low affinity for human serum sex hormone-binding globulin (SHBG), about 10% of that of testosterone and 2% of that of DHT. The drug metabolized in the liver by 6β-hydroxylation, 3α- and 3β-oxidation, 5β-reduction, 17-epimerization, and conjugation among other reactions. Unlike methyltestosterone, owing to the presence of its C1(2) double bond, Dianabol e.g, D-BOL does not produce 5α-reduced metabolites. The elimination half-life of Dianabol e.g, D-BOL is about 3 to 6 hours. Eliminated in the urine.
D-Bol Chemistry
Methandrostenolone, also known as 17α-methyl-δ1-testosterone or as 17α-methylandrost-1,4-dien-17β-ol-3-one, is a synthetic androstane steroid and a 17α-alkylated derivative of testosterone. It is a modification of testosterone with a methyl group at the C17α position and an additional double bond between the C1 and C2 positions. The drug is also the 17α-methylated derivative of boldenone (δ1-testosterone) and the δ1 analogue of methyltestosterone (17α-methyltestosterone).
Drug Testing and Detention of Use
Dianabol e.g, D-BOL is subject to hepatic biotransformation by a variety of enzymatic pathways. The primary urinary metabolites detectable for up to 3 days, and a recently discovered hydroxymethyl metabolite found in urine for up to 19 days after a single 5 mg. oral dose. Several of the metabolites are unique to Dianabol e.g, D-BOL. Methods for detection in urine specimens usually involve gas chromatography-mass spectrometry.
History Of D-Bol Use In Sports
Dianabol containing Methandrostenolone was first desgined in 1955. Synthesized by researchers at the CIBA laboratories in Basel, Switzerland. CIBA filed for a U.S. patent in 1957, and began marketing the drug as Dianabol in 1958 in the U.S. Initially prescribed to burn victims and the elderly. Also prescribed off-label as a pharmaceutical performance enhancement to weight lifters and other athletes. Early adopters included players for Oklahoma University and San Diego Chargers head coach Sid Gillman, who administered Dbol to his team starting in 1963. Later it became known as the choice anabolic-supplement of a Professional bodybulder named Arnold Schwarzenegger.
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Legal – FDA Vs. Ciba
After the Kefauver Harris Amendment passed in 1962, the U.S. FDA began the DESI review process to ensure the safety and efficacy of drugs approved under the more lenient pre-1962 standards, including Dianabol. In 1965, the FDA pressured CIBA to further document methandrostenolone’s legitimate medical uses, and re-approved the drug for treating post-menopausal osteoporosis and pituitary-deficient dwarfism. After CIBA’s patent exclusivity period lapsed, other manufacturers began to market generic “Dianabol” in the U.S.
Black Bolts
Following further FDA pressure, CIBA withdrew the methndrostenolone Dianabol from the U.S. market in 1983. Generic production shut down two years later, when the FDA revoked Dianabol e.g, D-BOL’s approval entirely in 1985. Non-medical use of methandrostenolone outlawed in the U.S. under the Anabolic Steroids Control Act of 1990. While methandrostenolone is controlled and no longer medically available in the U.S., products continue to be produced and sold legally in the United States absent of any banned ingredients under such names as DIANDROBOL™, DIANADROL®, DIANABOLIC™, and D-Anobol™.
Dianabol with Methandrostenolone confiscated by the Drug Enforcement Administration (DEA) in 2008.
Brand names
Methandrostenolone was originally introduced and formerly sold under the brand name “Dianabol”. It has also been marketed under a variety of other brand names including Anabol, Averbol, Chinlipan, Danabol, Dronabol, Metanabol, Methandon, Naposim, Reforvit-B, and Vetanabol among others. Dianabol is now a registered dietary supplement, which many refer to as a “legal steroid” supplement.
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Legal status
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Methandrostenolone, along with other androgenic anabolic steroids, a schedule III controlled substance in the United States under the Controlled Substances Act. The NEW DIANDROBOL supplement does not contain that ingredient and therefore, NOT illegal or dangerous. Marketed as a dietary supplement for bodybuilders that want bulk up. It is worth noting that “Dianabol” currently sold as a legal dietary supplement in the United States. Dianabol is LEGAL, as long as it does not contain methandrostenolone. All old versions of Dianabol containing methandrostenolone are illegal.